STMN1, stathmin 1, 3925

N. diseases: 284; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Based on these results, an influence of STMN1 should be considered in studies aiming at the etiopathogenesis of a broad range of neuropsychiatric disorders with dysfunctional networking, including neurodegenerative disorders as well as schizophrenia, autism spectrum disorders, anxiety disorders, depression, and ADHD. 21438138 2011
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Expression of p16(INK4a) and STMN1 was directly correlated with anxiety scores in the depression group, and that of p16(INK4a), STMN and TERT with the depression and anxiety scores in the combined sample (MDD plus controls). 23185405 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.320 Biomarker disease PSYGENET Correlative gene expression pattern linking RNF123 to cellular stress-senescence genes in patients with depressive disorder: implication of DRD1 in the cerebral cortex. 23668904 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET Correlative gene expression pattern linking RNF123 to cellular stress-senescence genes in patients with depressive disorder: implication of DRD1 in the cerebral cortex. 23668904 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET Expression of p16(INK4a) and STMN1 was directly correlated with anxiety scores in the depression group, and that of p16(INK4a), STMN and TERT with the depression and anxiety scores in the combined sample (MDD plus controls). 23185405 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET Based on these results, an influence of STMN1 should be considered in studies aiming at the etiopathogenesis of a broad range of neuropsychiatric disorders with dysfunctional networking, including neurodegenerative disorders as well as schizophrenia, autism spectrum disorders, anxiety disorders, depression, and ADHD. 21438138 2011
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.080 AlteredExpression group LHGDN Overexpression of oncoprotein 18 correlates with poor differentiation in lung adenocarcinomas. 12644570 2003
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.050 AlteredExpression disease LHGDN Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis. 16495930 2006
CUI: C0031511
Disease: Pheochromocytoma
Pheochromocytoma 		0.040 Biomarker disease LHGDN Stathmin was more highly expressed in pheochromocytomas compared to normal adrenals, a finding confirmed by Western blot. 18461287 2008
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.020 AlteredExpression disease LHGDN We suggest that the decreased protein level of stathmin in brains is associated with tangle formation and microtubule instability in DS as well as AD, but stathmin is not involved in the abnormal development of fetal DS brain. 11771751 2001
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.020 AlteredExpression disease LHGDN In addition, using mass spectrometry, stathmin was identified as the main component of a specific myelin protein fraction consistently increased in MS preparations compared with controls. 15659612 2005
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.010 AlteredExpression disease LHGDN We suggest that the decreased protein level of stathmin in brains is associated with tangle formation and microtubule instability in DS as well as AD, but stathmin is not involved in the abnormal development of fetal DS brain. 11771751 2001
CUI: C0023440
Disease: Acute Erythroblastic Leukemia
Acute Erythroblastic Leukemia 		0.010 AlteredExpression disease LHGDN In this study, we investigated the role of Op18 in PMA induced polyploidization during megakaryocyte differentiation of the human erythroleukemia cell line. 11922601 2001
CUI: C0028945
Disease: oligodendroglioma
oligodendroglioma 		0.010 GeneticVariation disease LHGDN The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. 17440165 2007
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.400 Biomarker disease CTD_human Prediction of metastatic relapse in node-positive breast cancer: establishment of a clinicogenomic model after FEC100 adjuvant regimen. 17659439 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.400 Biomarker disease CTD_human Prediction of metastatic relapse in node-positive breast cancer: establishment of a clinicogenomic model after FEC100 adjuvant regimen. 17659439 2008
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.400 Biomarker disease CTD_human Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling. 28284560 2017
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.360 Biomarker disease CTD_human Stathmin expression and phosphorylation patterns were analyzed in mouse and human PCa cell lines as well as in human PCa tissue arrays. 17455228 2007
CUI: C0017638
Disease: Glioma
Glioma 		0.350 Biomarker disease CTD_human The 1p-encoded protein stathmin and resistance of malignant gliomas to nitrosoureas. 17440165 2007
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.330 Biomarker group CTD_human cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene. 12376462 2002
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.320 Biomarker group CTD_human Stathmin levels increase early during normal mouse prostate development and again during prostate tumor development and progression. 17455228 2007
CUI: C0555198
Disease: Malignant Glioma
Malignant Glioma 		0.310 Biomarker disease CTD_human RNA inhibition and cDNA transfection experiments tested effects of stathmin under- and overexpression, respectively, on the in vitro and in vivo resistance of malignant glioma cells to treatment with nitrosourea. 17440165 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker group CTD_human Prediction of metastatic relapse in node-positive breast cancer: establishment of a clinicogenomic model after FEC100 adjuvant regimen. 17659439 2008
CUI: C0024667
Disease: Animal Mammary Neoplasms
Animal Mammary Neoplasms 		0.300 Biomarker phenotype CTD_human cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene. 12376462 2002
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.300 Biomarker phenotype CTD_human cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene. 12376462 2002